There is growing evidence that inflammation plays a major role in the pathogenesis of neural damage caused by deposition of amyloid β (Aβ) in the brain. Nimodipine has received attention as a drug that might improve learning and reduce cognitive deficits in Alzheimer's disease, but the mechanism of action is poorly known. In this study, we tested the hypothesis that nimodipine inhibited Aβ-stimulated IL-1β release from microglia.

Nimodipine inhibits IL-1β release stimulated by amyloid β from microglia

COLAIANNA, MARILENA;ZOTTI, MARGHERITA;TRABACE, LUIGIA;
2012-01-01

Abstract

There is growing evidence that inflammation plays a major role in the pathogenesis of neural damage caused by deposition of amyloid β (Aβ) in the brain. Nimodipine has received attention as a drug that might improve learning and reduce cognitive deficits in Alzheimer's disease, but the mechanism of action is poorly known. In this study, we tested the hypothesis that nimodipine inhibited Aβ-stimulated IL-1β release from microglia.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/319091
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