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Creatine supplementation and the role on oxidative stress, brain creatine level and inflammation. A brief review

Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review

Background Metabolic alkalosis may lead to respiratory inhibition and increased need for ventilatory support or prolongation of weaning from ventilation for patients with chronic respiratory disease. Acetazolamide can reduce alkalaemia and may reduce respiratory depression. Methods We searched Medline, EMBASE and CENTRAL from inception to March 2022 for randomised controlled trials comparing acetazolamide to placebo in patients with chronic obstructive pulmonary disease, obesity hyp...

“Brain trainer” and “exergames” in active ageing - “Brain trainer” ed “exergame” al servizio dell’invecchiamento attivo

Playing videogames can positively affect health and well-being in older adults, alleviating the loss of cognitive functions and promoting a better lifestyle. The videogame industry recently started to produce games and apps specifically aimed at promoting physical and cognitive training (exergames and “brain trainers”). Using these tools both for personal use and in therapeutic contexts is a promising approach; however, it depends on characteristics such as quality of design, accessibility, i...

The Effects of Curcumin on Inflammasome: Latest Update

Curcumin, a traditional Chinese medicine extracted from natural plant rhizomes, has become a candidate drug for the treatment of different diseases due to its anti-inflammatory, anticancer, antioxidant, and antibacterial activities. Curcumin is generally beneficial to improve human health with anti-inflammatory and antioxidative properties as well as antitumor and immunoregulatory properties. Inflammasomes are NLR family, pyrin domain-containing 3 (NLRP3) proteins that are activated in respon...

Mild to moderate mitral regurgitation in patients undergoing coronary bypass grafting: Effects on operative mortality and long-term significance

Background. Patients undergoing bypass grafting (CABG) often present with mitral regurgitation (MR). While surgical strategy for patients with either trace or severe MR is well established, the need for a valve procedure with mild (2) to moderate (3+) mitral regurgitation is controversial. Methods. We reviewed 1,939 consecutive CABG patients (1987 to 1999). A preoperative echocardiogram performed when clinically indicated graded MR from 1 to 4+. Patient characteristics, hospital mortality, an...

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