IRIS
LASELVA, ONOFRIO
 Distribuzione geografica
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Continente #
NA - Nord America 1.921
EU - Europa 1.626
AS - Asia 1.095
SA - Sud America 286
AF - Africa 28
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 2
Totale 4.961
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Nazione #
US - Stati Uniti d'America 1.837
SG - Singapore 520
IE - Irlanda 509
RU - Federazione Russa 289
IT - Italia 257
BR - Brasile 234
CN - Cina 160
HK - Hong Kong 158
SE - Svezia 132
UA - Ucraina 117
VN - Vietnam 106
FR - Francia 85
DE - Germania 73
CA - Canada 63
FI - Finlandia 54
IN - India 40
GB - Regno Unito 32
BD - Bangladesh 23
AR - Argentina 20
MX - Messico 14
NL - Olanda 14
TR - Turchia 13
IQ - Iraq 11
EC - Ecuador 9
PL - Polonia 9
AT - Austria 8
BE - Belgio 6
CL - Cile 6
CZ - Repubblica Ceca 6
ES - Italia 6
JP - Giappone 6
MA - Marocco 6
UZ - Uzbekistan 6
AE - Emirati Arabi Uniti 5
CO - Colombia 5
KE - Kenya 5
MK - Macedonia 5
PK - Pakistan 5
PY - Paraguay 5
ZA - Sudafrica 5
DK - Danimarca 4
ID - Indonesia 4
IR - Iran 4
PH - Filippine 4
TN - Tunisia 4
BG - Bulgaria 3
IL - Israele 3
JO - Giordania 3
SA - Arabia Saudita 3
TH - Thailandia 3
UY - Uruguay 3
AU - Australia 2
AZ - Azerbaigian 2
BS - Bahamas 2
DO - Repubblica Dominicana 2
EE - Estonia 2
ET - Etiopia 2
GR - Grecia 2
KG - Kirghizistan 2
KR - Corea 2
KZ - Kazakistan 2
LB - Libano 2
LT - Lituania 2
LV - Lettonia 2
NP - Nepal 2
PE - Perù 2
RO - Romania 2
TW - Taiwan 2
VE - Venezuela 2
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
CG - Congo 1
CH - Svizzera 1
DZ - Algeria 1
EG - Egitto 1
EU - Europa 1
JM - Giamaica 1
LC - Santa Lucia 1
LU - Lussemburgo 1
LY - Libia 1
MM - Myanmar 1
NI - Nicaragua 1
OM - Oman 1
PT - Portogallo 1
RS - Serbia 1
SN - Senegal 1
TO - Tonga 1
VA - Santa Sede (Città del Vaticano) 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 4.961
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Città #
Dublin 509
San Jose 400
Singapore 255
Chandler 241
Ashburn 190
Hong Kong 149
Nyköping 94
Santa Clara 77
The Dalles 65
Jacksonville 60
Dallas 59
Lauterbourg 56
Beijing 50
Princeton 46
Helsinki 44
Moscow 40
Ho Chi Minh City 37
Los Angeles 31
Wilmington 31
New York 28
Pune 23
Council Bluffs 22
Hanoi 22
Bari 19
Milan 16
Frankfurt am Main 15
Toronto 15
Des Moines 14
Nuremberg 13
Redwood City 13
São Paulo 13
Düsseldorf 11
Munich 11
Rio de Janeiro 11
Denver 9
Rome 9
San Mateo 9
Assago 8
Chicago 8
Haiphong 8
Manfredonia 8
Santa Marinella 8
Seattle 8
Atlanta 7
Cedar Knolls 7
Da Nang 7
Porto Alegre 7
Torino 7
Andria 6
Belo Horizonte 6
Paris 6
San Francisco 6
San Severo 6
Tashkent 6
Baghdad 5
Brno 5
Brooklyn 5
Brussels 5
Chennai 5
Cocoa 5
Dubai 5
Espoo 5
Falkenstein 5
Foggia 5
Guangzhou 5
Houghton 5
Johannesburg 5
Nairobi 5
Palermo 5
Portsmouth 5
Quito 5
Shanghai 5
Warsaw 5
Amsterdam 4
Boardman 4
Calgary 4
Campinas 4
Can Tho 4
Catania 4
Goiânia 4
Leawood 4
London 4
Naples 4
Ottawa 4
San Nicolás de los Garza 4
Skopje 4
Thái Bình 4
Tokyo 4
Turku 4
Vinhedo 4
Ankara 3
Aubervilliers 3
Barletta 3
Bismarck 3
Biên Hòa 3
Bắc Ninh 3
Caserta 3
Columbus 3
Contagem 3
Hamilton 3
Totale 3.019
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Nome #
D1152H MUTATION SHOWS A BICARBONATE BUT NOT A CHLORIDE DEFECT IN PRIMARY NASAL EPITHELIAL CELLS 147
Correctors of mutant CFTR enhance subcortical cAMP/PKA signaling via ezrin phosphorylation and cytoskeleton organization 145
Anti-Inflammatory and Anti-Oxidant Effect of Dimethyl Fumarate in Cystic Fibrosis Bronchial Epithelial Cells 145
AN ADENOVIRAL VECTOR EXPRESSING CFTR CAN BE USED TO BENCHMARK CFTR MODULATOR RESPONSES IN PATIENT-DERIVED NASAL EPITHELIAL CELLS 108
Human Amniotic Mesenchymal Stem Cells and Fibroblasts Accelerate Wound Repair of Cystic Fibrosis Epithelium 107
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system 105
Antisense oligonucleotide splicing modulation as a novel Cystic Fibrosis therapeutic approach for the W1282X nonsense mutation 103
Anticipating New Treatments for Cystic Fibrosis: A Global Survey of Researchers 100
Characterization of anti-proliferative and anti-oxidant effects of nano-sized vesicles from Brassica oleracea L. (Broccoli) 100
Lung Disease Management by Iloprost-Loaded Nanoparticles to Address Hyperinflammation Associated with Cystic Fibrosis 99
Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells 97
Anticipating New Treatments for Cystic Fibrosis: A Global Survey of Researchers 97
A helper-dependent adenoviral vector rescues CFTR to wild type functional levels in CF epithelial cells harbouring class I mutations 96
Comprehensive mapping of Cystic Fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site 94
IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression 91
Activity of Lumacaftor is not conserved in zebrafish Cftr bearing the major Cystic Fibrosis-causing mutation 91
MODULATION OF CFTR BY ITS PHOSPHORYLATION AND INTERACTION WITH SMALL MOLECULES 91
Human Amniotic Mesenchymal Stem Cells and Fibroblasts AccelerateWound Repair of Cystic Fibrosis Epithelium 90
Anti-infectives enhance ORKAMBI rescue of F508del-CFTR function in human bronchial epithelial cells infected with clinical strains of P. aeruginosa 90
Allele-specific prevention of nonsense-mediated decay in cystic fibrosis using homology-independent genome editing 88
Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ivacaftor mediated in part by the dual activities of Elexacaftor as both corrector and potentiator 88
Modulator Therapy in Cystic Fibrosis Patients with cis Variants in F508del Complex Allele: A Short-Term Observational Case Series 88
ASSESSING THE NEED FOR CORRECTOR COMBINATIONS FOR MISFOLDED CF VARIANTS OTHER THAN F508DEL 87
IL-17 family members exert an autocrine pro-inflammatory loop in CF respiratory epithelial cells ex vivo 86
Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains 84
The preclinical discovery and development of the combination of ivacaftor + tezacaftor used to treat cystic fibrosis 84
High-throughput functional analysis of CFTR and other apically localized proteins in iPSC-derived human intestinal organoids 84
Editorial: Mechanisms of Novel Drugs and Gene Modifiers in the Treatment of Cystic Fibrosis 83
MODELING CYSTIC FIBROSIS DISEASE AND THERAPIES IN PATIENT DERIVED TISSUES 82
Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes 82
Cholesterol interaction directly enhances intrinsic activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) 82
Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator 81
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients 81
The era of CFTR modulators: improvements made and remaining challenges 80
Olive Leaf Extract (OLE) as a Novel Antioxidant That Ameliorates the Inflammatory Response in Cystic Fibrosis 79
A protocol for identifying the binding sites of small molecules on the cystic fibrosis transmembrane conductance regulator (CFTR) protein 78
Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells 77
TOWARDS THE DETERMINATION OF THE BINDING SITE OF IVACAFTOR ON CFTR THROUGH USE OF PHOTOAFFINITY LABELING PROBES 77
STUDYING THE DISTINCT SENSITIVITIES OF CFTR MODULATORS USING ZEBRAFISH-CFTR 74
TRIMETHYLANGELICIN (TMA) BINDS DIRECTLY TO PURIFIED WILD-TYPE CFTR 73
Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector 72
HUMAN IPSCS AND NASAL CELL MODELS FOR CFTR THERATYPING 72
Phenotyping rare cftr mutations reveal functional expression defects restored by trikaftatm 72
Mucopenetration study of solid lipid nanoparticles containing magneto sensitive iron oxide 72
Trimethylangelicin promotes the functional rescue of F508del CFTR in CF airway cells 69
Small-molecule drugs for cystic fibrosis: Where are we now? 69
Deleterious effect of Pseudomonas aeruginosa on F508del-CFTR rescued by elexacaftor/tezacaftor/ivacaftor is clinical strain-dependent in patient-derived nasal cells 68
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function 68
Molecular mechanism of action of Trimethylangelicin derivatives as CFTR modulators 63
Deleterious effect ofP. aeruginosaon F508del-CFTR rescued by Elexacaftor/Tezacaftor/Ivacaftor is clinical-strain dependent in patient-derived nasal cells 62
Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants 62
Induced pluripotent stem cells for cystic fibrosis 59
Orkambi mediated rescue of mucociliary clearance in CF primary respiratory cultures is enhanced by arginine uptake, arginase inhibition and promotion of nitric oxide signalling to the CFTR channel 58
Generation of functional ciliated cholangiocytes from human pluripotent stem cells 58
The CFTR mutation c.3452G>C (D1152H) confers an anion selectivity defect in primary airway tissue that can be rescued by Ivacaftor 56
Advances in Preclinical In Vitro Models for the Translation of Precision Medicine for Cystic Fibrosis 54
The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved? 54
Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action 53
ORKAMBI/amplifier co-therapy rescues a rare CFTR mutation in gene-edited cells and patient tissue 53
One-Step Formation of Protein-Based Tubular Structures for Functional Devices and Tissues 52
The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain 49
Preclinical Studies of a Rare CF-Causing Mutation in the Second Nucleotide Binding Domain (c.3700A>G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators 49
Elexacaftor/Tezacaftor/Ivacaftor Accelerates Wound Repair in Cystic Fibrosis Airway Epithelium 49
Editorial: Mechanisms of action of small molecules on CFTR mutants and the impact on cystic fibrosis pathogenesis 32
Structure-guided combination of novel CFTR correctors to improve the function of F508del-CFTR in airway epithelial cells 32
Testing organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs 25
GY971 mitigates inflammation by reducing neutrophil recruitment in cystic fibrosis Ex Vivo and In Vivo models 7
Evaluation of ATP12A and NFKBIZ as potential markers of inflammatory status in cystic fibrosis airway epithelial cells 4
Totale 5.207
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Categoria #
all - tutte 33.927
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.927
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202148 0 0 0 0 0 0 0 0 0 0 0 48
2021/2022257 15 12 16 3 22 10 16 26 30 32 7 68
2022/20231.222 101 37 28 83 63 121 27 87 600 22 24 29
2023/2024287 31 16 9 8 13 77 16 57 0 7 13 40
2024/20251.047 68 13 22 42 17 221 67 70 246 77 132 72
2025/20261.985 161 156 210 299 118 103 325 210 130 108 62 103
Totale 5.207