IRIS
LASELVA, ONOFRIO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 2.046
EU - Europa 1.630
AS - Asia 1.106
SA - Sud America 287
Continente sconosciuto - Info sul continente non disponibili 248
AF - Africa 28
OC - Oceania 3
Totale 5.348
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 1.957
SG - Singapore 522
IE - Irlanda 509
RU - Federazione Russa 289
IT - Italia 260
BR - Brasile 234
CN - Cina 163
HK - Hong Kong 162
SE - Svezia 132
UA - Ucraina 118
VN - Vietnam 106
FR - Francia 85
DE - Germania 73
CA - Canada 64
FI - Finlandia 54
IN - India 40
GB - Regno Unito 32
BD - Bangladesh 25
AR - Argentina 21
MX - Messico 14
NL - Olanda 14
TR - Turchia 13
IQ - Iraq 11
EC - Ecuador 9
PL - Polonia 9
AT - Austria 8
BE - Belgio 6
CL - Cile 6
CZ - Repubblica Ceca 6
ES - Italia 6
JP - Giappone 6
MA - Marocco 6
UZ - Uzbekistan 6
AE - Emirati Arabi Uniti 5
CO - Colombia 5
KE - Kenya 5
MK - Macedonia 5
PK - Pakistan 5
PY - Paraguay 5
ZA - Sudafrica 5
DK - Danimarca 4
ID - Indonesia 4
IR - Iran 4
PH - Filippine 4
TN - Tunisia 4
BG - Bulgaria 3
DO - Repubblica Dominicana 3
IL - Israele 3
JO - Giordania 3
SA - Arabia Saudita 3
TH - Thailandia 3
UY - Uruguay 3
AU - Australia 2
AZ - Azerbaigian 2
BS - Bahamas 2
EE - Estonia 2
ET - Etiopia 2
GR - Grecia 2
KG - Kirghizistan 2
KR - Corea 2
KZ - Kazakistan 2
LB - Libano 2
LT - Lituania 2
LV - Lettonia 2
NP - Nepal 2
PE - Perù 2
RO - Romania 2
TW - Taiwan 2
VE - Venezuela 2
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
CG - Congo 1
CH - Svizzera 1
CR - Costa Rica 1
DZ - Algeria 1
EG - Egitto 1
EU - Europa 1
GT - Guatemala 1
HN - Honduras 1
JM - Giamaica 1
LC - Santa Lucia 1
LU - Lussemburgo 1
LY - Libia 1
MM - Myanmar 1
NI - Nicaragua 1
OM - Oman 1
PT - Portogallo 1
RS - Serbia 1
SN - Senegal 1
TO - Tonga 1
VA - Santa Sede (Città del Vaticano) 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 5.102
Salva come PNG Salva come JPEG
Città #
Dublin 509
San Jose 404
Singapore 257
Chandler 241
Ashburn 196
Hong Kong 153
Nyköping 94
Santa Clara 82
Council Bluffs 76
The Dalles 65
Dallas 60
Jacksonville 60
Lauterbourg 56
Beijing 51
Princeton 46
Helsinki 44
Moscow 40
Ho Chi Minh City 37
Columbus 31
Los Angeles 31
Wilmington 31
New York 28
Pune 23
Hanoi 22
Bari 19
Milan 16
Frankfurt am Main 15
Toronto 15
Des Moines 14
Nuremberg 13
Redwood City 13
São Paulo 13
Düsseldorf 11
Munich 11
Rio de Janeiro 11
Rome 10
Denver 9
San Mateo 9
Assago 8
Chicago 8
Haiphong 8
Manfredonia 8
Santa Marinella 8
Seattle 8
Atlanta 7
Cedar Knolls 7
Da Nang 7
Porto Alegre 7
Torino 7
Andria 6
Belo Horizonte 6
Paris 6
San Francisco 6
San Severo 6
Tashkent 6
Baghdad 5
Brno 5
Brooklyn 5
Brussels 5
Chennai 5
Cocoa 5
Dubai 5
Espoo 5
Falkenstein 5
Foggia 5
Guangzhou 5
Houghton 5
Johannesburg 5
Nairobi 5
Naples 5
Palermo 5
Portsmouth 5
Quito 5
Shanghai 5
Warsaw 5
Amsterdam 4
Boardman 4
Calgary 4
Campinas 4
Can Tho 4
Catania 4
Goiânia 4
Leawood 4
London 4
Ottawa 4
Phoenix 4
San Nicolás de los Garza 4
Skopje 4
Thái Bình 4
Tokyo 4
Turku 4
Vinhedo 4
Ankara 3
Aubervilliers 3
Barletta 3
Bismarck 3
Biên Hòa 3
Bắc Ninh 3
Caserta 3
Contagem 3
Totale 3.127
Salva come PNG Salva come JPEG
Nome #
D1152H MUTATION SHOWS A BICARBONATE BUT NOT A CHLORIDE DEFECT IN PRIMARY NASAL EPITHELIAL CELLS 150
Correctors of mutant CFTR enhance subcortical cAMP/PKA signaling via ezrin phosphorylation and cytoskeleton organization 146
Anti-Inflammatory and Anti-Oxidant Effect of Dimethyl Fumarate in Cystic Fibrosis Bronchial Epithelial Cells 146
AN ADENOVIRAL VECTOR EXPRESSING CFTR CAN BE USED TO BENCHMARK CFTR MODULATOR RESPONSES IN PATIENT-DERIVED NASAL EPITHELIAL CELLS 110
Human Amniotic Mesenchymal Stem Cells and Fibroblasts Accelerate Wound Repair of Cystic Fibrosis Epithelium 108
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system 107
Lung Disease Management by Iloprost-Loaded Nanoparticles to Address Hyperinflammation Associated with Cystic Fibrosis 104
Antisense oligonucleotide splicing modulation as a novel Cystic Fibrosis therapeutic approach for the W1282X nonsense mutation 104
Characterization of anti-proliferative and anti-oxidant effects of nano-sized vesicles from Brassica oleracea L. (Broccoli) 103
Anticipating New Treatments for Cystic Fibrosis: A Global Survey of Researchers 102
Anticipating New Treatments for Cystic Fibrosis: A Global Survey of Researchers 101
Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells 99
A helper-dependent adenoviral vector rescues CFTR to wild type functional levels in CF epithelial cells harbouring class I mutations 99
Comprehensive mapping of Cystic Fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site 95
Human Amniotic Mesenchymal Stem Cells and Fibroblasts AccelerateWound Repair of Cystic Fibrosis Epithelium 93
IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression 93
MODULATION OF CFTR BY ITS PHOSPHORYLATION AND INTERACTION WITH SMALL MOLECULES 93
Activity of Lumacaftor is not conserved in zebrafish Cftr bearing the major Cystic Fibrosis-causing mutation 92
Anti-infectives enhance ORKAMBI rescue of F508del-CFTR function in human bronchial epithelial cells infected with clinical strains of P. aeruginosa 91
IL-17 family members exert an autocrine pro-inflammatory loop in CF respiratory epithelial cells ex vivo 90
Modulator Therapy in Cystic Fibrosis Patients with cis Variants in F508del Complex Allele: A Short-Term Observational Case Series 90
Allele-specific prevention of nonsense-mediated decay in cystic fibrosis using homology-independent genome editing 89
Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ivacaftor mediated in part by the dual activities of Elexacaftor as both corrector and potentiator 89
Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells 88
ASSESSING THE NEED FOR CORRECTOR COMBINATIONS FOR MISFOLDED CF VARIANTS OTHER THAN F508DEL 88
High-throughput functional analysis of CFTR and other apically localized proteins in iPSC-derived human intestinal organoids 87
Editorial: Mechanisms of Novel Drugs and Gene Modifiers in the Treatment of Cystic Fibrosis 85
MODELING CYSTIC FIBROSIS DISEASE AND THERAPIES IN PATIENT DERIVED TISSUES 85
Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains 85
The preclinical discovery and development of the combination of ivacaftor + tezacaftor used to treat cystic fibrosis 85
Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes 84
Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator 84
Cholesterol interaction directly enhances intrinsic activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) 83
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients 82
A protocol for identifying the binding sites of small molecules on the cystic fibrosis transmembrane conductance regulator (CFTR) protein 80
Olive Leaf Extract (OLE) as a Novel Antioxidant That Ameliorates the Inflammatory Response in Cystic Fibrosis 80
The era of CFTR modulators: improvements made and remaining challenges 80
Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector 77
TOWARDS THE DETERMINATION OF THE BINDING SITE OF IVACAFTOR ON CFTR THROUGH USE OF PHOTOAFFINITY LABELING PROBES 77
STUDYING THE DISTINCT SENSITIVITIES OF CFTR MODULATORS USING ZEBRAFISH-CFTR 76
TRIMETHYLANGELICIN (TMA) BINDS DIRECTLY TO PURIFIED WILD-TYPE CFTR 75
Phenotyping rare cftr mutations reveal functional expression defects restored by trikaftatm 73
Mucopenetration study of solid lipid nanoparticles containing magneto sensitive iron oxide 73
HUMAN IPSCS AND NASAL CELL MODELS FOR CFTR THERATYPING 72
Deleterious effect of Pseudomonas aeruginosa on F508del-CFTR rescued by elexacaftor/tezacaftor/ivacaftor is clinical strain-dependent in patient-derived nasal cells 71
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function 71
Trimethylangelicin promotes the functional rescue of F508del CFTR in CF airway cells 70
Small-molecule drugs for cystic fibrosis: Where are we now? 70
Deleterious effect ofP. aeruginosaon F508del-CFTR rescued by Elexacaftor/Tezacaftor/Ivacaftor is clinical-strain dependent in patient-derived nasal cells 67
Molecular mechanism of action of Trimethylangelicin derivatives as CFTR modulators 66
Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants 62
Induced pluripotent stem cells for cystic fibrosis 62
Orkambi mediated rescue of mucociliary clearance in CF primary respiratory cultures is enhanced by arginine uptake, arginase inhibition and promotion of nitric oxide signalling to the CFTR channel 61
Generation of functional ciliated cholangiocytes from human pluripotent stem cells 60
The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved? 57
The CFTR mutation c.3452G>C (D1152H) confers an anion selectivity defect in primary airway tissue that can be rescued by Ivacaftor 57
Advances in Preclinical In Vitro Models for the Translation of Precision Medicine for Cystic Fibrosis 56
One-Step Formation of Protein-Based Tubular Structures for Functional Devices and Tissues 55
ORKAMBI/amplifier co-therapy rescues a rare CFTR mutation in gene-edited cells and patient tissue 54
Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action 53
Preclinical Studies of a Rare CF-Causing Mutation in the Second Nucleotide Binding Domain (c.3700A>G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators 51
Elexacaftor/Tezacaftor/Ivacaftor Accelerates Wound Repair in Cystic Fibrosis Airway Epithelium 50
The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain 49
Structure-guided combination of novel CFTR correctors to improve the function of F508del-CFTR in airway epithelial cells 36
Editorial: Mechanisms of action of small molecules on CFTR mutants and the impact on cystic fibrosis pathogenesis 33
Testing organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs 26
GY971 mitigates inflammation by reducing neutrophil recruitment in cystic fibrosis Ex Vivo and In Vivo models 10
Evaluation of ATP12A and NFKBIZ as potential markers of inflammatory status in cystic fibrosis airway epithelial cells 8
Totale 5.348
Salva come PNG Salva come JPEG
Categoria #
all - tutte 35.293
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.293
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022242 0 12 16 3 22 10 16 26 30 32 7 68
2022/20231.222 101 37 28 83 63 121 27 87 600 22 24 29
2023/2024287 31 16 9 8 13 77 16 57 0 7 13 40
2024/20251.047 68 13 22 42 17 221 67 70 246 77 132 72
2025/20261.988 161 156 210 299 118 103 325 210 130 108 62 106
2026/2027138 35 103 0 0 0 0 0 0 0 0 0 0
Totale 5.348