This study was designed to evaluate the influence of iv infusion (50 ng kg-1 min-1) of epinephrine, norepinephrine, and isoproterenol on glucose homeostasis in normal man. Epinephrine infusion produced a 40-45 mg/dl increment of plasma glucose concentration which resulted from both a transient 85-90% rise in glucose production (P<0.005) and the failure of glucose uptake to increase consistently in response to hyperglycemia. Plasma insulin increased slightly (20-25%), while plasma glucagon remained unchanged. Norepinephrine infusion produced a much smaller increase in glucose production (25-30%) and plasma glucose (10-15 mg/dl) compared to epinephrine (P<0.01 and P<0.025, respectively). The increase in glucose output was very transient and was not followed by a significant elevation of glucose uptake. Plasma insulin and glucagon levels remained unchanged. The infusion of isoproterenol resulted in a 30-35% increase in glucose production (P<0.025) which remained at levels significantly above baseline throughout the entire study period and was accompanied by a proportional and sustained increase in glucose uptake (P<0.025). As a consequence, plasma glucose increased by only 8-10 mg/dl. Plasma insulin rose 2- to 3-fold in response to isoproterenol (P<0.05), whereas plasma glucagon was unaffected. It is concluded that 1) epinephrine-induced hyperglycemia in normal man is mediated by a transient stimulation of hepatic glucose output and a sustained inhibition of glucose uptake; 2) norepinephrine produces a small and very transient stimulation of glucose output and has no effect on glucose uptake (in contrast, isoproterenol causes a sustained activation of glucose production followed by a proportional elevation of glucose uptake); and 3) the stimulatory effect of epinephrine, norepinephrine, and isoproterenol on hepatic glucose output is not mediated by glucagon hypersecretion.

Influence of epinephrine, norepinephrine, and isoproterenol on glucose homeostasis in normal man.

Corso G;
1980

Abstract

This study was designed to evaluate the influence of iv infusion (50 ng kg-1 min-1) of epinephrine, norepinephrine, and isoproterenol on glucose homeostasis in normal man. Epinephrine infusion produced a 40-45 mg/dl increment of plasma glucose concentration which resulted from both a transient 85-90% rise in glucose production (P<0.005) and the failure of glucose uptake to increase consistently in response to hyperglycemia. Plasma insulin increased slightly (20-25%), while plasma glucagon remained unchanged. Norepinephrine infusion produced a much smaller increase in glucose production (25-30%) and plasma glucose (10-15 mg/dl) compared to epinephrine (P<0.01 and P<0.025, respectively). The increase in glucose output was very transient and was not followed by a significant elevation of glucose uptake. Plasma insulin and glucagon levels remained unchanged. The infusion of isoproterenol resulted in a 30-35% increase in glucose production (P<0.025) which remained at levels significantly above baseline throughout the entire study period and was accompanied by a proportional and sustained increase in glucose uptake (P<0.025). As a consequence, plasma glucose increased by only 8-10 mg/dl. Plasma insulin rose 2- to 3-fold in response to isoproterenol (P<0.05), whereas plasma glucagon was unaffected. It is concluded that 1) epinephrine-induced hyperglycemia in normal man is mediated by a transient stimulation of hepatic glucose output and a sustained inhibition of glucose uptake; 2) norepinephrine produces a small and very transient stimulation of glucose output and has no effect on glucose uptake (in contrast, isoproterenol causes a sustained activation of glucose production followed by a proportional elevation of glucose uptake); and 3) the stimulatory effect of epinephrine, norepinephrine, and isoproterenol on hepatic glucose output is not mediated by glucagon hypersecretion.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/8637
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