We read with great interest the article by Muthumala and colleagues on behalf of the HIFMECH Study Group, which reported findings on the impact of the ACE I/D polymorphism on risk of myocardial infarction (MI) in relation to possible differences in Northern compared to Southern Europe. The ACE gene, located on chromosome 17, has an insertion (I allele)/deletion (D allele) genetic polymorphism in its non-coding region and homozygosity of the ACE D allele has also been associated with an increased risk for MI. This polymorphism has been recently associated with an increased risk for development of sporadic Alzheimer's disease (AD) and findings of a higher prevalence of ACE D allele in a large cohort of French centenarians compared with younger elderly controls have suggested a possible protective role for the ACE polymorphism in longevity.
|Titolo:||Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different ages.|
|Data di pubblicazione:||2007|
|Appare nelle tipologie:||1.1 Articolo in rivista|