Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression and therapeutic outcome. These processes are mediated by various cytokines. Recent findings suggest that therapeutic mind-body protocols, can reduce the expression of genes associated with inflammation and stress-related pathways. An interventional, non-pharmacological, randomized study on patients with breast cancer was carried out to validate the genomic and epigenetic effects of the mind-body transformations technique (MBT-T). 28 patients were recruited at the end of the standard adjuvant treatments. Patients were randomly assigned to standard follow-up (control arm) or to the standard follow-up + MBT-T intervention (experimental arm). The experimental procedure requested the addition of a biweekly psychological treatment lasting 4 months. The blood samples have been collected before the treatment, 1 h after, 2 months after and at the end of it. Our preliminary results seem indicate that MBT-T induce a reduction of the release of different cytokines and chemokines in the breast cancer patients compared to a control group. This research underlining the importance of integrated mind-body protocols for improving the outcome in breast cancer.

MIND-BODY TRANSFORMATIONS-THERAPY (MBT-T) IN BREAST CANCER PATIENTS: CLINICAL AND INFLAMMATORY EFFECTS WITH PSYCHOSOCIAL GENOMICS APPROACH

Celia G.
Writing – Original Draft Preparation
2022-01-01

Abstract

Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression and therapeutic outcome. These processes are mediated by various cytokines. Recent findings suggest that therapeutic mind-body protocols, can reduce the expression of genes associated with inflammation and stress-related pathways. An interventional, non-pharmacological, randomized study on patients with breast cancer was carried out to validate the genomic and epigenetic effects of the mind-body transformations technique (MBT-T). 28 patients were recruited at the end of the standard adjuvant treatments. Patients were randomly assigned to standard follow-up (control arm) or to the standard follow-up + MBT-T intervention (experimental arm). The experimental procedure requested the addition of a biweekly psychological treatment lasting 4 months. The blood samples have been collected before the treatment, 1 h after, 2 months after and at the end of it. Our preliminary results seem indicate that MBT-T induce a reduction of the release of different cytokines and chemokines in the breast cancer patients compared to a control group. This research underlining the importance of integrated mind-body protocols for improving the outcome in breast cancer.
978-88-6938-316-8
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/427408
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