The effect of a crude thymic extract from calf, TP-1, has been evaluated on the bacterial binding to peripheral blood lymphocytes (PBL) from 12 cancer patients undergoing chemotherapy. Two parameters of Salmonella minnesota R345 (Rb) adherence to PBL have been analyzed, namely the percentage of binding lymphocytes (BL) and the number of bound bacteria/lymphocytes (BB). Results show that in 5 patients not receiving TP-1 the BB was significantly reduced in comparison with 7 patients, who were subjected to TP-1 administration plus chemotherapy. In conclusion, these data indicate that chemotherapy causes a reduction of receptor expression for Salmonella on PBL, while TP-1 prevents this effect by mechanisms which need to be further clarified.

Cancer patients undergoing chemotherapy possess a reduced number of binding sites for Salmonella organisms on peripheral blood lymphocytes. Effects of Timostimolina (TP-1) administration

Maffione A. B.;
1991

Abstract

The effect of a crude thymic extract from calf, TP-1, has been evaluated on the bacterial binding to peripheral blood lymphocytes (PBL) from 12 cancer patients undergoing chemotherapy. Two parameters of Salmonella minnesota R345 (Rb) adherence to PBL have been analyzed, namely the percentage of binding lymphocytes (BL) and the number of bound bacteria/lymphocytes (BB). Results show that in 5 patients not receiving TP-1 the BB was significantly reduced in comparison with 7 patients, who were subjected to TP-1 administration plus chemotherapy. In conclusion, these data indicate that chemotherapy causes a reduction of receptor expression for Salmonella on PBL, while TP-1 prevents this effect by mechanisms which need to be further clarified.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/418236
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