Plexiform neurofibroma of the penis associated with erectile dysfunction due to arterial steeling

Introduction: Solitary involvement of the genitourinary tract by Von Recklinghousen disease (VRD) is extremely rare. Aims: This report documents the management of a case of a plexiform neurofibroma on the penile shaft associated with erectile dysfunction. The literature surrounding VRD and its effects on the genital area was also investigated. Methods. After a complete preoperative investigation of the nature of the mass and of the erectile dysfunction, the neurofibroma was completely excised with preservation of the neurovascular bundle. Results: At 6-months postoperative follow-up, there was no sign of tumor recurrence and the glans sensation was maintained. The erectile dysfunction persisted postoperatively and failed to respond to medical treatment. Conclusions: A complete excision of penile neurofibromas is mandatory to prevent recurrence or malignant degeneration and can be safely performed preserving the neurovascular bundle.