2-Chloromethyl-2-oxazoline converts cleanly into trans-1,2,3-tris(oxazolinyl)cyclopropane upon treatment with strong bases such as LDA or KN(SiMe3)2. Deprotonation of the above cyclopropane followed by the addition of electrophiles allows the preparation of more functionalized tris-(oxazolinyl)cyclopropanes.
Metalation of 2-chloromethyl-2-oxazolines: Synthesis of 1,2,3-tris(oxazolinyl)cyclopropanes and derivatives
Rocchetti M. T.
2002-01-01
Abstract
2-Chloromethyl-2-oxazoline converts cleanly into trans-1,2,3-tris(oxazolinyl)cyclopropane upon treatment with strong bases such as LDA or KN(SiMe3)2. Deprotonation of the above cyclopropane followed by the addition of electrophiles allows the preparation of more functionalized tris-(oxazolinyl)cyclopropanes.File in questo prodotto:
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