Introduction: heart failure (HF) has been defined a modern pandemic. The complex array of physiologic, psychological, social and health care issues makes it a challenging chronic disease to diagnose and manage. Our study is aimed to evaluate a multi-markers approach in diagnosis of HF in aged males. Methods: 68 Italian males aged >65 years have been enrolled; 25 were patients with heart failure (HF) and 43 were healthy controls. In all the subjects, measurements of high sensitivity troponin I (TNI), galectin-3 (GAL), cystatin C (CYS) and brain natriuretic peptide (BNP) were performed using routine methods. Results: in patients with HF, mean concentrations of TNI, GAL, CYS and BNP were significantly higher (p<0.001) than values observed in controls subjects. Only BNP and GAL showed a correlation with NHYA stage of HF. In this study, GAL and BNP demonstrated better diagnostic perfomamces to differentiate of HF patients from controls subjects. Conclusions: our study showed the usefulness of a strategy involving multiple biomarkers determination in laboratory diagnosis of HF in elderly males.
Comparative study of galectin-3, brain natriuretic peptide, cystantine C and high sensitivity troponin determinations in the diagnosis of heart failure in elderly Italian males
Iacoviello M.;
2019-01-01
Abstract
Introduction: heart failure (HF) has been defined a modern pandemic. The complex array of physiologic, psychological, social and health care issues makes it a challenging chronic disease to diagnose and manage. Our study is aimed to evaluate a multi-markers approach in diagnosis of HF in aged males. Methods: 68 Italian males aged >65 years have been enrolled; 25 were patients with heart failure (HF) and 43 were healthy controls. In all the subjects, measurements of high sensitivity troponin I (TNI), galectin-3 (GAL), cystatin C (CYS) and brain natriuretic peptide (BNP) were performed using routine methods. Results: in patients with HF, mean concentrations of TNI, GAL, CYS and BNP were significantly higher (p<0.001) than values observed in controls subjects. Only BNP and GAL showed a correlation with NHYA stage of HF. In this study, GAL and BNP demonstrated better diagnostic perfomamces to differentiate of HF patients from controls subjects. Conclusions: our study showed the usefulness of a strategy involving multiple biomarkers determination in laboratory diagnosis of HF in elderly males.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
