Objective: Besides wheat allergy (WA) and celiac disease (CD) the spectrum of gluten related disorders recently included a new entity: Gluten Sensitivity (GS). So far GS has been described only in adults: herein, we describe clinical, serological and histological characteristic of the first pediatric series of GS. Study Design: 45 children were studied: 15 (F:5; mean age: 9,6±3,9) with GS diagnosed because of clear-cut relationship between wheat consumption and development of symptoms, after excluding CD and WA; 15 children (F:10; mean age: 9,1±3,1) with active CD and 15 controls (F:9; mean age 8,6±2,7) with functional gastrointestinal disorders. All underwent: a) CD panel (AGA-IgG and IgA, TTG-IgA, and -IgG and EMA-IgA); b) hematological parameters (Hb, iron, ferritin, GOT, ESR); c) HLA; d) small intestinal biopsy (on voluntary basis in GS). Results: Abdominal pain was the most prevalent symptom (80% of GS), followed by chronic diarrhoea in (73%), tiredness (33%), bloating (26%), limb pain, vomiting, constipation, headache (20%) and failure to thrive (13%). AGA-IgG was positive in 66% one of GS children. No difference was found in nutritional, biochemical and inflammatory markers between GS and controls. HLA-DQ2 was found in 7 GS children. Histology revealed a normal to mildly inflamed mucosa (Marsh 0-1) in GS patients. Conclusion: The present study represents the first description of pediatric cases of GS, supporting the existence of this condition in children across all ages with clinical, serological, genetic and histological features similar to adults.

Clinical, Serological and Histological Features of Gluten Sensitivity in Children

Indrio F;
2013-01-01

Abstract

Objective: Besides wheat allergy (WA) and celiac disease (CD) the spectrum of gluten related disorders recently included a new entity: Gluten Sensitivity (GS). So far GS has been described only in adults: herein, we describe clinical, serological and histological characteristic of the first pediatric series of GS. Study Design: 45 children were studied: 15 (F:5; mean age: 9,6±3,9) with GS diagnosed because of clear-cut relationship between wheat consumption and development of symptoms, after excluding CD and WA; 15 children (F:10; mean age: 9,1±3,1) with active CD and 15 controls (F:9; mean age 8,6±2,7) with functional gastrointestinal disorders. All underwent: a) CD panel (AGA-IgG and IgA, TTG-IgA, and -IgG and EMA-IgA); b) hematological parameters (Hb, iron, ferritin, GOT, ESR); c) HLA; d) small intestinal biopsy (on voluntary basis in GS). Results: Abdominal pain was the most prevalent symptom (80% of GS), followed by chronic diarrhoea in (73%), tiredness (33%), bloating (26%), limb pain, vomiting, constipation, headache (20%) and failure to thrive (13%). AGA-IgG was positive in 66% one of GS children. No difference was found in nutritional, biochemical and inflammatory markers between GS and controls. HLA-DQ2 was found in 7 GS children. Histology revealed a normal to mildly inflamed mucosa (Marsh 0-1) in GS patients. Conclusion: The present study represents the first description of pediatric cases of GS, supporting the existence of this condition in children across all ages with clinical, serological, genetic and histological features similar to adults.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/389848
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 75
  • ???jsp.display-item.citation.isi??? 55
social impact