IMPORTANCE Recurrent abdominal pain is a prevalent health issue in childhood. Clinical criteria (ie, the Rome criteria) have been established to aid diagnosis. Studies of adults have shown an increased prevalence of celiac disease among patients with irritable bowel syndrome (IBS); few data are available with regard to children. OBJECTIVE Toassesstheprevalenceofceliacdiseaseamongchildrenwithabdominal pain–related functional gastrointestinal disorders classified according to the Rome criteria. DESIGN,SETTING,PARTICIPANTS Six-year(2006-2012)prospectivecohortstudyconductedin a tertiary referral center for the diagnosis and follow-up of gastrointestinal disorders in southern Italy (ie, Bari, Italy). A total of 992 children (42.8% male; median age, 6.8 years) consecutively referred for recurrent abdominal pain by their primary care physicians without previous investigation were evaluated. EXPOSURE PatientswereclassifiedaccordingtoRomeIIIcriteriaashavingIBS,functional dyspepsia, functional abdominal pain, or abdominal migraine. MAINOUTCOMESANDMEASURES Prevalenceofceliacdiseaseineachcategoryofabdominal pain–related functional gastrointestinal disorder. Concentrations of IgA, IgA antitissue transglutaminase, and endomysial antibodies were measured, and a duodenal biopsy was performed in case of antibody positivity.
Increased prevalence of celiac disease among pediatric patients with irritable bowel syndrome: a 6-year prospective cohort study
Indrio F;
2014-01-01
Abstract
IMPORTANCE Recurrent abdominal pain is a prevalent health issue in childhood. Clinical criteria (ie, the Rome criteria) have been established to aid diagnosis. Studies of adults have shown an increased prevalence of celiac disease among patients with irritable bowel syndrome (IBS); few data are available with regard to children. OBJECTIVE Toassesstheprevalenceofceliacdiseaseamongchildrenwithabdominal pain–related functional gastrointestinal disorders classified according to the Rome criteria. DESIGN,SETTING,PARTICIPANTS Six-year(2006-2012)prospectivecohortstudyconductedin a tertiary referral center for the diagnosis and follow-up of gastrointestinal disorders in southern Italy (ie, Bari, Italy). A total of 992 children (42.8% male; median age, 6.8 years) consecutively referred for recurrent abdominal pain by their primary care physicians without previous investigation were evaluated. EXPOSURE PatientswereclassifiedaccordingtoRomeIIIcriteriaashavingIBS,functional dyspepsia, functional abdominal pain, or abdominal migraine. MAINOUTCOMESANDMEASURES Prevalenceofceliacdiseaseineachcategoryofabdominal pain–related functional gastrointestinal disorder. Concentrations of IgA, IgA antitissue transglutaminase, and endomysial antibodies were measured, and a duodenal biopsy was performed in case of antibody positivity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
