Co-ultramicronized palmitoylethanolamide/luteolin treatment as add-on to intensive neuro-rehabilitation in a young patient with traumatic brain injury

Traumatic brain injury (TBI) is a complex injury with a broad spectrum of symptoms and disabilities. The aim of this report was to present the case history of a young patient with TBI undergoing neurorehabilitation and treated with a composite of co-ultramicronized palmitoylethanolamide (PEA) and luteolin (co-ultraPEALut) as add-on therapy to medical care. A 12-year-old boy with TBI from a bicycle-car accident was admitted to the neurorehabilitation department after two months of recovery in the intensive care unit for coma; his Glasgow Coma Scale was 3. At the time of admission the patient was placed on a treatment with a composite co-ultraPEALut (GLIALIA®) as add-on therapy to intensive neurorehabilitative care. At the end of the treatment period the patient showed a clear improvement in functional symptoms and in consciousness, greater than would have been expected from our historical experience with patients in this condition at admission to our unit. The progressive recovery in motor and cognitive functions observed in the patient with a minimally conscious state, suggest that co-ultraPEALut may be an innovative therapeutic approach to the complex neurological condition of TBI and may be considered a new therapeutic opportunity in add-on to neurorehabilitative care.