BACKGROUND: During laparoscopy, respiratory mechanics and gas exchange are impaired because of pneumoperitoneum and atelectasis formation. We applied an open lung approach (OLA ) consisting in lung recruitment followed by a decremental positive-end expiratory pressure (PEE P) trial to identify the level of PEE P corresponding to the highest compliance of the respiratory system (best PEE P). Our hypothesis was that this approach would improve both lung mechanics and oxygenation without hemodynamic impairment. METHODS: We studied twenty patients undergoing laparoscopic cholecystectomy. We continuously recorded respiratory mechanics parameters throughout a decremental PEE P trial in order to identify the best PEE P level. Furthermore, lung and chest wall mechanics, respiratory and transpulmonary driving pressures (ΔP), gas exchange and hemodynamics were recorded at three time-points: 1) after pneumoperitoneum induction (TpreOLA ); 2) after the application of the OLA (TpostOLA ); 3) at the end of surgery, after abdominal deflation (Tend). RESULTS : The “best PEE P” level was 8.1±1.3 cmH2O (range 6 to 10 cmH2O), corresponding to the highest compliance of the respiratory system (CRS ). This “best PEEP” level corresponded with lowest ΔPL. OLA increased the compliance of the lung and of the chest wall, and decreased ΔPRS and ΔPL. PaO2/FiO2 increased from 299±125 mmHg to 406±101 mmHg (P=0.04). Changes in respiratory mechanics, driving pressures and oxygenation were maintained until Tend. Hemodynamic parameters remained stable throughout the study period. CONCLUSIONS: In patients undergoing laparoscopic cholecystectomy, the OLA was suitable for bedside PEE P setting, improved lung mechanics and gas exchange without significant adverse hemodynamic effects.

Physiological effects of the open lung approach during laparoscopic cholecystectomy: focus on driving pressure

D'ANTINI, DAVIDE
Membro del Collaboration Group
;
RAUSEO, MICHELA
Writing – Original Draft Preparation
;
MIRABELLA, LUCIA
Methodology
;
COTOIA, ANTONELLA
Membro del Collaboration Group
;
FERSINI, ALBERTO
Membro del Collaboration Group
;
PETTA, ROCCO
Membro del Collaboration Group
;
Dambrosio, Michele
Membro del Collaboration Group
;
CINNELLA, GILDA
Conceptualization
2018-01-01

Abstract

BACKGROUND: During laparoscopy, respiratory mechanics and gas exchange are impaired because of pneumoperitoneum and atelectasis formation. We applied an open lung approach (OLA ) consisting in lung recruitment followed by a decremental positive-end expiratory pressure (PEE P) trial to identify the level of PEE P corresponding to the highest compliance of the respiratory system (best PEE P). Our hypothesis was that this approach would improve both lung mechanics and oxygenation without hemodynamic impairment. METHODS: We studied twenty patients undergoing laparoscopic cholecystectomy. We continuously recorded respiratory mechanics parameters throughout a decremental PEE P trial in order to identify the best PEE P level. Furthermore, lung and chest wall mechanics, respiratory and transpulmonary driving pressures (ΔP), gas exchange and hemodynamics were recorded at three time-points: 1) after pneumoperitoneum induction (TpreOLA ); 2) after the application of the OLA (TpostOLA ); 3) at the end of surgery, after abdominal deflation (Tend). RESULTS : The “best PEE P” level was 8.1±1.3 cmH2O (range 6 to 10 cmH2O), corresponding to the highest compliance of the respiratory system (CRS ). This “best PEEP” level corresponded with lowest ΔPL. OLA increased the compliance of the lung and of the chest wall, and decreased ΔPRS and ΔPL. PaO2/FiO2 increased from 299±125 mmHg to 406±101 mmHg (P=0.04). Changes in respiratory mechanics, driving pressures and oxygenation were maintained until Tend. Hemodynamic parameters remained stable throughout the study period. CONCLUSIONS: In patients undergoing laparoscopic cholecystectomy, the OLA was suitable for bedside PEE P setting, improved lung mechanics and gas exchange without significant adverse hemodynamic effects.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/358837
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