Alzheimer's disease (AD) induces a widespread patho-logical extracellular accumulation of beta-amyloid (Ab) peptides that affects cortical networks underpin- ning cognitive functions. This is related to abnormal functional and effective brain connectivity as revealed by graph markers of resting-state eyes-closed electro-encephalographic (EEG) rhythms. Here we revised EEG studies in mild cognitive impairment and AD subjects showing that these markers are promising network disease endpoints for basic research and AD drug discovery.

Resting state EEG rhythms as network disease markers for drug discovery in alzheimer's disease

BABILONI, CLAUDIO;INFARINATO, FRANCESCO;TRIGGIANI, ANTONIO IVANO;Lizio, Roberta;Del Percio, Claudio;Marzano, Nicola;
2013-01-01

Abstract

Alzheimer's disease (AD) induces a widespread patho-logical extracellular accumulation of beta-amyloid (Ab) peptides that affects cortical networks underpin- ning cognitive functions. This is related to abnormal functional and effective brain connectivity as revealed by graph markers of resting-state eyes-closed electro-encephalographic (EEG) rhythms. Here we revised EEG studies in mild cognitive impairment and AD subjects showing that these markers are promising network disease endpoints for basic research and AD drug discovery.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/358002
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