Microvesicles (MVs) are cell-derived vesicles produced after membrane remodeling of eukaryotic cells during activation or apoptosis. MVs are considered a novel biomarker/messenger for many diseases. Neurons, astrocytes, microglia, as well as neural stem cells, have been described to release MVs, many studies have demonstrated the involvement of platelets and endothelial MVs in some central nervous diseases. This review is focused on understanding the role of MVs in the brain; new findings demonstrated that MVs can contribute to the onset and progression of some neurodegenerative and neuroinflammatory diseases, as well as to the development and regeneration of the nervous system.

Microvesicles in the brain: Biomarker, messenger or mediator?

PORRO, CHIARA
Writing – Review & Editing
;
TROTTA, TERESA;
2015-01-01

Abstract

Microvesicles (MVs) are cell-derived vesicles produced after membrane remodeling of eukaryotic cells during activation or apoptosis. MVs are considered a novel biomarker/messenger for many diseases. Neurons, astrocytes, microglia, as well as neural stem cells, have been described to release MVs, many studies have demonstrated the involvement of platelets and endothelial MVs in some central nervous diseases. This review is focused on understanding the role of MVs in the brain; new findings demonstrated that MVs can contribute to the onset and progression of some neurodegenerative and neuroinflammatory diseases, as well as to the development and regeneration of the nervous system.
File in questo prodotto:
File Dimensione Formato  
journal of neuroimmunology 2015(microparticles in the brain).pdf

solo utenti autorizzati

Tipologia: PDF Editoriale
Licenza: Dominio pubblico
Dimensione 465.77 kB
Formato Adobe PDF
465.77 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11369/332724
Citazioni
  • ???jsp.display-item.citation.pmc??? 29
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 58
social impact