A multicenter survey of adverse drug reaction to anticonvulsants was conducted in 15 university and hospital departments. Five hundred and nine patients undergoing chronic anticonvulsant therapy were admitted to the study. The proportion of cases with adverse drug reaction was 22% in patients receiving monotherapy, 34.2% in patients treated with two drugs, and 44.4% in patients receiving three or more drugs. Thirthy-thrree percent of patients taking phenytoin as the only drug had adverse drug reaction as compared with 23, 15, and 12% of patients treated with phenobarbital, carbazepine, and sodium valproate or depamide. Somnolence was the coomonest complaint, followed by gingival hyperplasia, nystagmus, and ataxia. This represents a valuable complement to the information available in anticonvulsant toxicity in the literature
Adverse reactions to antiepileptic drugs: a multicenter survey of clinical practice.
SPECCHIO, LUIGI MARIA
1986-01-01
Abstract
A multicenter survey of adverse drug reaction to anticonvulsants was conducted in 15 university and hospital departments. Five hundred and nine patients undergoing chronic anticonvulsant therapy were admitted to the study. The proportion of cases with adverse drug reaction was 22% in patients receiving monotherapy, 34.2% in patients treated with two drugs, and 44.4% in patients receiving three or more drugs. Thirthy-thrree percent of patients taking phenytoin as the only drug had adverse drug reaction as compared with 23, 15, and 12% of patients treated with phenobarbital, carbazepine, and sodium valproate or depamide. Somnolence was the coomonest complaint, followed by gingival hyperplasia, nystagmus, and ataxia. This represents a valuable complement to the information available in anticonvulsant toxicity in the literatureI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
