The examination of centenarian populations for the frequency of certain alleles of pertinent genes may provide insights into the human longevity. To study the relationships between angiotensin converting enzyme (ACE) polymorphism and longevity at the lower extreme of Europe, we evaluated 63 centenarians and 204 younger middle-aged controls (19-80 years) to confirm previous data on increased prevalence of the high-risk ACE*D allele in French centenarians. No statistically significant differences were found in ACE genotype and allele frequencies between centenarians and younger controls in this Southern Italy population. We hypothesized that the variability in the strength of association between ACE polymorphism and longevity could be related to regional differences in ACE*D frequency in Europe, as recently reported for apoE ε2 and ε4 allele in centenarians.
Apolipoprotein and antiotensin converting enzyme genes: regional differences and extreme longevity in Europe.
Solfrizzi V;Capurso C;
2002-01-01
Abstract
The examination of centenarian populations for the frequency of certain alleles of pertinent genes may provide insights into the human longevity. To study the relationships between angiotensin converting enzyme (ACE) polymorphism and longevity at the lower extreme of Europe, we evaluated 63 centenarians and 204 younger middle-aged controls (19-80 years) to confirm previous data on increased prevalence of the high-risk ACE*D allele in French centenarians. No statistically significant differences were found in ACE genotype and allele frequencies between centenarians and younger controls in this Southern Italy population. We hypothesized that the variability in the strength of association between ACE polymorphism and longevity could be related to regional differences in ACE*D frequency in Europe, as recently reported for apoE ε2 and ε4 allele in centenarians.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
