Heavy metals are known to pollute the environment and can be taken up by the organism in food. They can accumulate within organs and tissues, with sometimes dramatic effects. Heavy-metal accumulation in the brain seems to be involved in neuro- degenerative conditions, such as Alzheimer's disease (AD). Recent reports have shown the presence of heavy metals in senile plaques, hallmarks of AD, constituted of ABPI- 40 and ABP1-42 peptide deposits. There is increasing evidence that heavy metals can interact with amyloid ẞ peptides, contributing to the neurodegenerative events of AD. In this study, we analyse ABP1-42 incorporation and channel formation in planar lipid membranes (PLMs) and the effects of calcium and cadmium ions on ABP1-42 channel activity.
Effect of calcium and cadmium ions on amyloid beta peptide 1-42 channel activity
MELELEO D;
2009-01-01
Abstract
Heavy metals are known to pollute the environment and can be taken up by the organism in food. They can accumulate within organs and tissues, with sometimes dramatic effects. Heavy-metal accumulation in the brain seems to be involved in neuro- degenerative conditions, such as Alzheimer's disease (AD). Recent reports have shown the presence of heavy metals in senile plaques, hallmarks of AD, constituted of ABPI- 40 and ABP1-42 peptide deposits. There is increasing evidence that heavy metals can interact with amyloid ẞ peptides, contributing to the neurodegenerative events of AD. In this study, we analyse ABP1-42 incorporation and channel formation in planar lipid membranes (PLMs) and the effects of calcium and cadmium ions on ABP1-42 channel activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
