Biological membranes, depicted being as composed of a fluid bilayer considered to be a uniform semi-permeable barrier, have evolved into a complex and dynamic environment in which lipid assembly forms a fluid platform that segregates membrane components into a sort of patchwork of domains. Cholesterol, an essential component of animal cell membranes whose concentration is tightly controlled by a feedback system, is often found in domains in biological and model membranes. A wide variety of physiological functions such as signal transduction processes, pathogen entry, protein sorting and trafficking, modulation of peptide incorporation and channel formation - have been attributed to these domains. The focus of this review is to gain some understanding on how membrane cholesterol and closely-related sterols modulate some proteins.
Modulation of some membrane proteins by cholesterol and related sterols
MELELEO, DANIELA ADDOLORATA;
2009-01-01
Abstract
Biological membranes, depicted being as composed of a fluid bilayer considered to be a uniform semi-permeable barrier, have evolved into a complex and dynamic environment in which lipid assembly forms a fluid platform that segregates membrane components into a sort of patchwork of domains. Cholesterol, an essential component of animal cell membranes whose concentration is tightly controlled by a feedback system, is often found in domains in biological and model membranes. A wide variety of physiological functions such as signal transduction processes, pathogen entry, protein sorting and trafficking, modulation of peptide incorporation and channel formation - have been attributed to these domains. The focus of this review is to gain some understanding on how membrane cholesterol and closely-related sterols modulate some proteins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
