Sfoglia per Autore
Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ivacaftor mediated in part by the dual activities of Elexacaftor as both corrector and potentiator
2020-01-01 Laselva, Onofrio; Bartlett, Claire; Gunawardena, Tarini N A; Ouyang, Hong; Eckford, Paul D W; Moraes, Theo J; Bear, Christine E; Gonska, Tanja
Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants
2020-01-01 Laselva, O.; Bartlett, C.; Popa, A; Ouyang, H.; Gunawardena, T. N. A.; Gonska, T.; Moraes, T. J.; Bear, C. E.
Anti-infectives enhance ORKAMBI rescue of F508del-CFTR function in human bronchial epithelial cells infected with clinical strains of P. aeruginosa
2020-01-01 Laselva, O.; Stone, T. A.; Bear, C. E.; Deber, C. R.
The era of CFTR modulators: improvements made and remaining challenges
2020-01-01 Cuevas-Ocaña, Sara; Laselva, Onofrio; Avolio, Julie; Nenna, Raffaella
Preclinical Studies of a Rare CF-Causing Mutation in the Second Nucleotide Binding Domain (c.3700A>G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators
2020-01-01 Laselva, Onofrio; Mccormack, Jacqueline; Bartlett, Claire; Ip, Wan; Gunawardena, Tarini N. A.; Ouyang, Hong; Eckford, Paul D. W.; Gonska, Tanja; Moraes, Theo J.; Bear, Christine E.
The preclinical discovery and development of the combination of ivacaftor + tezacaftor used to treat cystic fibrosis
2020-01-01 Guerra, L.; Favia, M.; Di Gioia, S.; Laselva, O.; Bisogno, A.; Casavola, V.; Colombo, C.; Conese, M.
Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes
2020-01-01 Rizwan, Muhammad; Fokina, Ana; Kivijärvi, Tove; Ogawa, Mina; Kufleitner, Markus; Laselva, Onofrio; Smith, Laura J.; Bear, Christine E.; Ogawa, Shinichiro; Keller, Gordon; Shoichet, and Molly S.
The CFTR mutation c.3452G>C (D1152H) confers an anion selectivity defect in primary airway tissue that can be rescued by Ivacaftor
2020-01-01 Laselva, O.; Moraes, T.; He, G.; Bartlett, C.; Szarics, I.; Ouyang, H.; Strug, L.; Bear, C. E.; Gonska, T
Allele-specific prevention of nonsense-mediated decay in cystic fibrosis using homology-independent genome editing
2020-01-01 Erwood, S.; Laselva, O.; Bily, T. M. I.; Rutherford, A. H.; BEAR C. E. IVAKINE E., A
A helper-dependent adenoviral vector rescues CFTR to wild type functional levels in CF epithelial cells harbouring class I mutations
2020-01-01 Cao, H.; Ouyang, H.; Laselva, O.; Bartlett, C.; Zhou, Z. P. DUAN C.; Gunawardena, T.; Avolio, J.; Bear, C. E.; Gonska, T.; Hu, J.; Moraes, T. J.
High-throughput functional analysis of CFTR and other apically localized proteins in iPSC-derived human intestinal organoids
2021-01-01 Xia, S.; Bozoky, Z.; Di Paola, M.; Laselva, O.; Ahmadi, S.; Jiang, J. X.; Pitstick, A. L.; Jiang, C.; Rotin, D.; Mayhew, C. N.; Jones, N. L.; Bear, C. E.
Generation of functional ciliated cholangiocytes from human pluripotent stem cells
2021-01-01 Ogawa, Mina; Jiang, Jia-Xin; Xia, Sunny; Yang, Donghe; Ding, Avrilynn; Laselva, Onofrio; Hernandez, Marcela; Cui, Changyi; Higuchi, Yuichiro; Suemizu, Hiroshi; Dorrell, Craig; Grompe, Markus; Bear, Christine E; Ogawa, Shinichiro
Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator
2021-01-01 Laselva, O.; Qureshi, Z.; Zeng, Z. -W.; Petrotchenko, E. V.; Ramjeesingh, M.; Hamilton, C. M.; Huan, L. -J.; Borchers, C. H.; Pomes, R.; Young, R.; Bear, C. E.
Anti-Inflammatory and Anti-Oxidant Effect of Dimethyl Fumarate in Cystic Fibrosis Bronchial Epithelial Cells
2021-01-01 Laselva, Onofrio; Allegretta, Caterina; DI GIOIA, Sante; Avolio, Carlo; Conese, Massimo
Antisense oligonucleotide splicing modulation as a novel Cystic Fibrosis therapeutic approach for the W1282X nonsense mutation
2021-01-01 Oren, Y. S.; Avizur-Barchad, O.; Ozeri-Galai, E.; Elgrabli, R.; Schirelman, M. R.; Blinder, T.; Stampfer, C. D.; Ordan, M.; Laselva, O.; Cohen-Cymberknoh, M.; Kerem, E.; Bear, C. E.; Kerem, B.
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients
2021-01-01 Jiang, Jia Xin; Wellhauser, Leigh; Laselva, Onofrio; Utkina, Irina; Bozoky, Zoltan; Gunawardena, Tarini; Ngan, Zoe; Xia, Sunny; Di Paola, Michelle; Eckford, Paul D W; Ratjen, Felix; Moraes, Theo J; Parkinson, John; Wong, Amy P; Bear, Christine E
Phenotyping rare cftr mutations reveal functional expression defects restored by trikaftatm
2021-01-01 Laselva, O.; Ardelean, M. C.; Bear, C. E.
One-Step Formation of Protein-Based Tubular Structures for Functional Devices and Tissues
2021-01-01 Gao, W.; Vaezzadeh, N.; Chow, K.; Chen, H.; Lavender, P.; Jeronimo, M. D.; Mcallister, A.; Laselva, O.; Jiang, J. -X.; Gage, B. K.; Ogawa, S.; Ramchandran, A.; Bear, C. E.; Keller, G. M.; Gunther, A.
Mucopenetration study of solid lipid nanoparticles containing magneto sensitive iron oxide
2022-01-01 Castellani, S.; Trapani, A.; Elisiana Carpagnano, G.; Cotoia, A.; Laselva, O.; Pia Foschino Barbaro, M.; Corbo, F.; Cinnella, G.; De Giglio, E.; Larobina, D.; Di Gioia, S.; Conese, M.
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function
2022-01-01 Ngan, Shuk Yee; Quach, Henry T; Laselva, Onofrio; Huang, Elena N; Mangos, Maria; Xia, Sunny; Bear, Christine E; Wong, Amy P
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ivacaftor mediated in part by the dual activities of Elexacaftor as both corrector and potentiator | 1-gen-2020 | Laselva, Onofrio; Bartlett, Claire; Gunawardena, Tarini N A; Ouyang, Hong; Eckford, Paul D W; Moraes, Theo J; Bear, Christine E; Gonska, Tanja | |
| Emerging preclinical modulators developed for F508del-CFTR have the potential to be effective for ORKAMBI resistant processing mutants | 1-gen-2020 | Laselva, O.; Bartlett, C.; Popa, A; Ouyang, H.; Gunawardena, T. N. A.; Gonska, T.; Moraes, T. J.; Bear, C. E. | |
| Anti-infectives enhance ORKAMBI rescue of F508del-CFTR function in human bronchial epithelial cells infected with clinical strains of P. aeruginosa | 1-gen-2020 | Laselva, O.; Stone, T. A.; Bear, C. E.; Deber, C. R. | |
| The era of CFTR modulators: improvements made and remaining challenges | 1-gen-2020 | Cuevas-Ocaña, Sara; Laselva, Onofrio; Avolio, Julie; Nenna, Raffaella | |
| Preclinical Studies of a Rare CF-Causing Mutation in the Second Nucleotide Binding Domain (c.3700A>G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators | 1-gen-2020 | Laselva, Onofrio; Mccormack, Jacqueline; Bartlett, Claire; Ip, Wan; Gunawardena, Tarini N. A.; Ouyang, Hong; Eckford, Paul D. W.; Gonska, Tanja; Moraes, Theo J.; Bear, Christine E. | |
| The preclinical discovery and development of the combination of ivacaftor + tezacaftor used to treat cystic fibrosis | 1-gen-2020 | Guerra, L.; Favia, M.; Di Gioia, S.; Laselva, O.; Bisogno, A.; Casavola, V.; Colombo, C.; Conese, M. | |
| Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes | 1-gen-2020 | Rizwan, Muhammad; Fokina, Ana; Kivijärvi, Tove; Ogawa, Mina; Kufleitner, Markus; Laselva, Onofrio; Smith, Laura J.; Bear, Christine E.; Ogawa, Shinichiro; Keller, Gordon; Shoichet, and Molly S. | |
| The CFTR mutation c.3452G>C (D1152H) confers an anion selectivity defect in primary airway tissue that can be rescued by Ivacaftor | 1-gen-2020 | Laselva, O.; Moraes, T.; He, G.; Bartlett, C.; Szarics, I.; Ouyang, H.; Strug, L.; Bear, C. E.; Gonska, T | |
| Allele-specific prevention of nonsense-mediated decay in cystic fibrosis using homology-independent genome editing | 1-gen-2020 | Erwood, S.; Laselva, O.; Bily, T. M. I.; Rutherford, A. H.; BEAR C. E. IVAKINE E., A | |
| A helper-dependent adenoviral vector rescues CFTR to wild type functional levels in CF epithelial cells harbouring class I mutations | 1-gen-2020 | Cao, H.; Ouyang, H.; Laselva, O.; Bartlett, C.; Zhou, Z. P. DUAN C.; Gunawardena, T.; Avolio, J.; Bear, C. E.; Gonska, T.; Hu, J.; Moraes, T. J. | |
| High-throughput functional analysis of CFTR and other apically localized proteins in iPSC-derived human intestinal organoids | 1-gen-2021 | Xia, S.; Bozoky, Z.; Di Paola, M.; Laselva, O.; Ahmadi, S.; Jiang, J. X.; Pitstick, A. L.; Jiang, C.; Rotin, D.; Mayhew, C. N.; Jones, N. L.; Bear, C. E. | |
| Generation of functional ciliated cholangiocytes from human pluripotent stem cells | 1-gen-2021 | Ogawa, Mina; Jiang, Jia-Xin; Xia, Sunny; Yang, Donghe; Ding, Avrilynn; Laselva, Onofrio; Hernandez, Marcela; Cui, Changyi; Higuchi, Yuichiro; Suemizu, Hiroshi; Dorrell, Craig; Grompe, Markus; Bear, Christine E; Ogawa, Shinichiro | |
| Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator | 1-gen-2021 | Laselva, O.; Qureshi, Z.; Zeng, Z. -W.; Petrotchenko, E. V.; Ramjeesingh, M.; Hamilton, C. M.; Huan, L. -J.; Borchers, C. H.; Pomes, R.; Young, R.; Bear, C. E. | |
| Anti-Inflammatory and Anti-Oxidant Effect of Dimethyl Fumarate in Cystic Fibrosis Bronchial Epithelial Cells | 1-gen-2021 | Laselva, Onofrio; Allegretta, Caterina; DI GIOIA, Sante; Avolio, Carlo; Conese, Massimo | |
| Antisense oligonucleotide splicing modulation as a novel Cystic Fibrosis therapeutic approach for the W1282X nonsense mutation | 1-gen-2021 | Oren, Y. S.; Avizur-Barchad, O.; Ozeri-Galai, E.; Elgrabli, R.; Schirelman, M. R.; Blinder, T.; Stampfer, C. D.; Ordan, M.; Laselva, O.; Cohen-Cymberknoh, M.; Kerem, E.; Bear, C. E.; Kerem, B. | |
| A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients | 1-gen-2021 | Jiang, Jia Xin; Wellhauser, Leigh; Laselva, Onofrio; Utkina, Irina; Bozoky, Zoltan; Gunawardena, Tarini; Ngan, Zoe; Xia, Sunny; Di Paola, Michelle; Eckford, Paul D W; Ratjen, Felix; Moraes, Theo J; Parkinson, John; Wong, Amy P; Bear, Christine E | |
| Phenotyping rare cftr mutations reveal functional expression defects restored by trikaftatm | 1-gen-2021 | Laselva, O.; Ardelean, M. C.; Bear, C. E. | |
| One-Step Formation of Protein-Based Tubular Structures for Functional Devices and Tissues | 1-gen-2021 | Gao, W.; Vaezzadeh, N.; Chow, K.; Chen, H.; Lavender, P.; Jeronimo, M. D.; Mcallister, A.; Laselva, O.; Jiang, J. -X.; Gage, B. K.; Ogawa, S.; Ramchandran, A.; Bear, C. E.; Keller, G. M.; Gunther, A. | |
| Mucopenetration study of solid lipid nanoparticles containing magneto sensitive iron oxide | 1-gen-2022 | Castellani, S.; Trapani, A.; Elisiana Carpagnano, G.; Cotoia, A.; Laselva, O.; Pia Foschino Barbaro, M.; Corbo, F.; Cinnella, G.; De Giglio, E.; Larobina, D.; Di Gioia, S.; Conese, M. | |
| Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function | 1-gen-2022 | Ngan, Shuk Yee; Quach, Henry T; Laselva, Onofrio; Huang, Elena N; Mangos, Maria; Xia, Sunny; Bear, Christine E; Wong, Amy P |
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